Cytokine signaling
Use this workflow to summarize immune signaling between cell populations.
Research questions
- Which sender/receiver pairs have strong ligand-receptor scores?
- Which cytokine pathways are prominent?
- Which signaling pathways differ by disease, treatment, or response group?
Suggested path
- Register expression and metadata inputs.
- Run
cell_communication. - Review signaling bubbles, communication matrix, pathway heatmap table, and comparative deltas.
- Generate interpretation from completed communication runs.
Outputs to cite
- interaction score
- pathway score
- ligand activity score
- comparative delta
- p-value when permutations are requested